Matthew 27:34
Vinegar--mingled with gall; Mark names "wine mingled with myrrh," an intensely bitter substance. Though it may have been intended as a stupefying draught, it still belonged to the process of a bloody, ignominious, and agonizing death. Thus was fulfilled the prophecy in Ps 69:21. In persecuting the Saviour, accusing and condemning him; in giving him vinegar and gall to drink, parting his garments among them and casting lots on his vesture, and never ceasing to afflict him till he gave up the ghost, all concerned were free and accountable; and though doing it with wicked hands and wicked hearts, they were fulfilling the predictions of God, and thus proving that Jesus was the Messiah.
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