Isaiah 49:21
21. Who, &c.--Zion's joyful wonder at the unexpected restoration of the ten tribes. Secondarily, the accession of spiritual Israelites to the mother church of Jerusalem from the Gentiles is meant. This created surprise at first (Ac 10:45; 14:27; 15:3, 4). lost ... am desolate, a captive, and removing to and fro--rather, "bereaved of ... have been barren, an exile and outcast" [Horsley]. She had been "put away" by Jehovah, her husband (Is 50:1); hence her wonder at the children begotten to her.
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